Cellular adaptations to microgravity
Main Supervisor
Prof. Engin Özçivici (IZTECH)
Supervisors
Asst. Prof. Nesli Erdogmus (IZTECH)
Assoc. Prof. Bora Garipcan (BOUN)
Recruiting Institution
İzmir Institute of Technology, Graduate School, Urla/İzmir
About the Course
Scientific Context of the Project
Mechanical signals are essential determinants of cell function and fate. Cessation or absence of mechanical loads such as a sedentary lifestyle, bedrest, stroke or spaceflight leads to a deterioration of tissue health in many organs.
For this study, we are interested in bone marrow mimicking 3D cultures and their response to microgravity. On earth microgravity will be facilitated by magnetic manipulation of cells, using diamagnetic levitation systems. Molecular and cellular adaptations to magnetic levitation will be documented and compared to in vivo studies as well as recorded spaceflight data.
Innovative Aspects of the Project
Ground-based microgravity assessment tools based on magnetic levitation.
Research Environment and Infrastructure
PhD candidates will be expected to work in an interdisciplinary environment with access to cell/tissue culture; cellular imaging and molecular biology tools as well as magnetic levitation-based culture technologies.
Preferred Academic Background
Biomedical Engineering, Bioengineering, Molecular Biology and Genetics
Required GRE Score
GRE Quantitative 157.00Scientific Context of the Project
Mechanical signals are essential determinants of cell function and fate. Cessation or absence of mechanical loads such as a sedentary lifestyle, bedrest, stroke or spaceflight leads to a deterioration of tissue health in many organs.
For this study, we are interested in bone marrow mimicking 3D cultures and their response to microgravity. On earth microgravity will be facilitated by magnetic manipulation of cells, using diamagnetic levitation systems. Molecular and cellular adaptations to magnetic levitation will be documented and compared to in vivo studies as well as recorded spaceflight data.
Innovative Aspects of the Project
Ground-based microgravity assessment tools based on magnetic levitation.
Research Environment and Infrastructure
PhD candidates will be expected to work in an interdisciplinary environment with access to cell/tissue culture; cellular imaging and molecular biology tools as well as magnetic levitation-based culture technologies.
Preferred Academic Background
Biomedical Engineering, Bioengineering, Molecular Biology and Genetics
Required GRE Score
GRE Quantitative 157.00
Your Instructor
İzmir Institute of Technology, Graduate School
